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Shimomura Y - J Nutr - 01-JUN-2004; 134(6 Suppl): 1583S-1587S

"Branched-chain amino acids (BCAAs) are essential amino acids that can be oxidized in skeletal muscle. It is known that BCAA oxidation is promoted by exercise. The mechanism responsible for this phenomenon is attributed to activation of the branched-chain alpha-keto acid dehydrogenase (BCKDH) complex, which catalyzes the second-step reaction of the BCAA catabolic pathway and is the rate-limiting enzyme in the pathway. This enzyme complex is regulated by a phosphorylation-dephosphorylation cycle. The BCKDH kinase is responsible for inactivation of the complex by phosphorylation, and the activity of the kinase is inversely correlated with the activity state of the BCKDH complex, which suggests that the kinase is the primary regulator of the complex. We found recently that administration of ligands for peroxisome proliferator-activated receptor-alpha (PPARalpha) in rats caused activation of the hepatic BCKDH complex in association with a decrease in the kinase activity, which suggests that promotion of fatty acid oxidation upregulates the BCAA catabolism. Long-chain fatty acids are ligands for PPARalpha, and the fatty acid oxidation is promoted by several physiological conditions including exercise. These findings suggest that fatty acids may be one of the regulators of BCAA catabolism and that the BCAA requirement is increased by exercise. Furthermore, BCAA supplementation before and after exercise has beneficial effects for decreasing exercise-induced muscle damage and promoting muscle-protein synthesis; this suggests the possibility that BCAAs are a useful supplement in relation to exercise and sports."

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"Am J Physiol Endocrinol Metab. 2004 Nov 23;

The combined ingestion of protein and free leucine with carbohydrate increases post-exercise muscle protein synthesis in vivo in male subjects.

Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ.

Department of Human Biology, Nutrition Research Institute Maastricht (NUTRIM Maastricht University, Maastricht, The Netherlands.

The present study was designed to determine post-exercise muscle protein synthesis and whole-body protein balance following the combined ingestion of carbohydrate with or without protein and/or free leucine. Eight male subjects were randomly assigned to 3 trials in which they consumed drinks containing either carbohydrate (CHO), carbohydrate and protein (CHO+PRO), or carbohydrate, protein and free leucine (CHO+PRO+leu) following 45 min of resistance exercise. A primed, continuous infusion of L-[ring-(13)C6]phenylalanine was applied, with blood samples and muscle biopsies collected to assess fractional synthetic rate (FSR) in the m. vastus lateralis as well as whole-body protein turnover during 6 h of post-exercise recovery. Plasma insulin response was higher in the CHO+PRO+leu compared to the CHO and CHO+PRO trials (+240+/-19% and +77+/-11%, respectively, P<0.05). Whole-body protein breakdown rates were lower, and whole-body protein synthesis rates were higher in the CHO+PRO and CHO+PRO+leu trials compared to the CHO trial (P<0.05). Addition of leucine in the CHO+PRO+leu trial resulted in a lower protein oxidation rate compared to the CHO+PRO trial. Protein balance was negative during recovery in the CHO trial, but positive in the CHO+PRO and CHO+PRO+leu trials. In the CHO+PRO+leu trial, whole-body net protein balance was significantly greater compared to values observed in the CHO+PRO and CHO trials (P<0.05). Mixed muscle FSR, measured over a 6h period of post-exercise recovery, was significantly greater in the CHO+PRO+leu trial compared to the CHO trial (0.095+/-0.006 %(.)h(-1) vs. 0.061+/-0.008 %(.)h(-1), respectively; P<0.05), with intermediate values observed in the CHO+PRO trial (0.0820 +/- 0.0104 %(.)h(-1)). We conclude that the co-ingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole-body protein balance when compared to the intake of carbohydrate only."

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Li na internet um artigo sobre ABCDE - " ANABOLIC BURST CYCLING of DIET and EXERCISE " .

Não entendi muita coisa . Alguem sabe do que se trata ?

Agora sobre o BCAA .

Suplemente com 8 caps de bcaa depois de um treino massacrante que vc vai ver se dá ou não dá efeito .

A médica não malha , é como o personal , se vc aperfeiçoa um movimento que está no manual dele ele logo fala que tá errado , nem testa pra ver .

Flw .

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Li na internet um artigo sobre ABCDE - " ANABOLIC BURST CYCLING of DIET and EXERCISE " .

Não entendi muita coisa . Alguem sabe do que se trata ?

Agora sobre o BCAA .

Suplemente com 8 caps de bcaa depois de um treino massacrante que vc vai ver se dá ou não dá efeito .

A médica não malha , é como o personal , se vc aperfeiçoa um movimento que está no manual dele ele logo fala que tá errado , nem testa pra ver . Eu faço alguns exercícios que eu mesmo adaptei . Tô numa boa .

Flw .

é uma dieta, onde voce intercala um periodo comendo feito um touro e outro de baixissima injestao de calorias...

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